Sunday, May 24, 2020
Essay Topics For College - Essay Topics for College: Eye DisorderIf you have a question about essay topics for college, it is very likely that you are suffering from my eye disorder. Many people are interested in the topic of eyesight issues and the other problems that come with age, but this does not mean that they are concerned about the readers when writing essays.If you are one of the many people that have poor eyesight, and you have been looking for ways to get the advice and help that you need, there are many options available. The first thing that you should do is to contact your optometrist. Your optometrist will be able to tell you if you are qualified to get prescriptions for glasses or whether it is something that you need to talk to a doctor about.Since your optometrist will be able to help you with the problem, you will want to keep your eye disorder topics in mind when you begin your essay topics for college. The doctor will want to know if you are having problems with your ability to focus on objects that are close up. It could be that your pupil size is getting smaller as you age, causing blurry vision. Your optometrist will be able to examine your eyes and tell you what the right course of action is.One option that many people consider is changing your diet, so they can lessen their risk of eye disorder. What most people do not realize is that they do not necessarily need to change their diets. It is possible that a healthy lifestyle can lead to better eyesight and help you avoid eye disorder.Another option that you may want to consider is testing yourself for a cause of your eye disorder. If you have an eye disorder, you may have issues that are related to the eye as well.If you suffer from an eye disorder, you may want to make an appointment with your doctor and see if you can find out why you have such problems. If you have any questions about your eyesight, your optometrist can give you the information that you need. This information can th en help you decide what type of medication to take, if any, to help you get better eyesight.If you suffer from an eye disorder, you may want to speak to your optometrist about your eyesight, so that you can learn more about what the problem is. The eye care specialist can give you advice and tips about what to do about the problem. You will then be able to find out what kind of treatment you need to help you get better eyesight.Having an eye disorder is something that no one wants to deal with, but it is something that is unfortunately necessary. Before you reach out for any prescription drugs, find out how you can get better eyesight without using any drugs. If you feel that your eyesight is getting worse, speak to your optometrist to find out what the problem is.
Wednesday, May 6, 2020
Ã¢â¬ËA tiny sixteen-month-old child toddles off down the garden path. Close behind her follow two adults. She pauses, looks around and says meaningfully: Ã¢â¬Å"Windy.Ã¢â¬ The adults scribble furiously in their Woolworths notepads.Ã¢â¬â¢ Homes all over the world, scenarios like this are repeated in a way to experience every tiny word said by the child, it is almost an achievement and a breakthrough for some parents to hear their child say, Ã¢â¬ËmamaÃ¢â¬â¢ or Ã¢â¬ËdadÃ¢â¬â¢ for the first time but what is put into this development is what is earned back. Language acquisition is established all around the intellectual development of a child. Considering turn of events, health, education and upbringings, the acquirement of a language when fully acquired allows one to make sense of the world they live in. Maria Montessori (1870-1952) who was one of the most innovative childhood pedagogues of the 20th Century had argued that each and every child has a unique potential for growth and development waiting to be expressed and revealed. Aforesaid potential is best advanced by allowing children to be free to explore and manipulate the surrounding environment. Her concept basically suggested that in hands-on, multi-modality activities, learning fixated on creating mental modes but having adult observation followed by appropriate adult intervention worked better, thus Ã¢â¬ËstructuredÃ¢â¬â¢. Notably language, it is the core of the apparatus to be human that is why childÃ¢â¬â¢s growth and development in language has received the mostShow MoreRelatedMaria Montessori : Education Of Children And Developed A Clear Concept Of A Plan ned Environment1489 Words Ã |Ã 6 Pages Ã¢â¬Æ' While Maria Montessori expressed multiple convincing theories regarding the education of children that included ideas such as sensitive periods, the role of independence and a planned environment in the classroom, some theories contradicted each other and in practice. She compiled her beliefs into a Montessori Method that described how to teach young children in a way that fulfilled their full potential. McClureÃ¢â¬â¢s magazine recognized Montessori as a Ã¢â¬Å"wonder worker in educationÃ¢â¬ (Tozier, 1911)Read MoreMaria said that the children have an inner force, it gives them the strength and energy to achieve900 Words Ã |Ã 4 PagesMaria said that the children have an inner force, it gives them the strength and energy to achieve potentially. When you give a child guidance and freedom, they focus mainly on what they need to know. Children have more confidence and they do not need to rely on the teachers. Maria had put optimism and humanism in her teaching. Montessori approach, she made the school beautiful and careful environment for the children. Didactic materials, so she could meet the needs of each child at their level ofRead MoreHow Does the Montessori Environment Facilitate and Encourage the Freedom of the Child?750 Words Ã |Ã 3 PagesIn a Montessori classroom, a child is free to move about and explore the environment because with activity and movement comes learning. Movement, in fact, contributes not only to the physical, but also to the intellectual potential and spiritual development of the child. The child must have freedom achieved through order and self-discipline. The child in a Montessori environment can learn, discover and be creative. He has the freedom of choice and develops his individual interest. The child learnsRead MoreThe influence of the Absorbent Mind, and the Sensitive Periods on the childs development of movement, language and social skills.1448 Words Ã |Ã 6 Pagesinfluence of these periods on the child s development of movement, language and social skills. A child in his absorbent mind develops his movement, his language and social skills by soaking knowledge. He takes steps in different sensitive period and repeats his movements, words or social skill actions to improve and to perfect his movement, language and social skills. The Absorbent Mind: Dr. Maria Montessori uses the term Absorbent Mind to describe the child s mental capacity for soaking upRead MoreMontessori : History And Developmental Theory1043 Words Ã |Ã 5 Pageshead: Maria Montessori Maria Montessori - History and Developmental Theory Kelsie Nesbitt Georgian College Abstract This paper will explore Maria Montessori and her theories on early childhood education. Using information that I find online and through the Introduction to ECE textbook, I will create an organized research report describing how and why Maria Montessori has had such a huge impact on early childhood education today. After furthering my knowledge with research on Maria MontessoriRead MoreMaria Montessori1462 Words Ã |Ã 6 PagesMaria Montessori Julianne Perry ECE101: Introduction to Early Childhood Education Monica Kelly June 13, 2011 Thesis: Maria Montessori s way of learning is very unique; her theory was for children learn in a natural and parent-supported environment. Outline I. Education of Montessori 1. First woman to receive a Medical Degree in Italy A. Studied psychiatry, education and anthropology. B. Worked, wrote and spoke for children with special needs 2. Many schoolsRead MoreReview of the Montessori Method1375 Words Ã |Ã 6 PagesÃ¢â¬Å"The Montessori MethodÃ¢â¬ Review Paper Lisa Ahlgrim National Louis University Maria Montessori was a visionary woman, passionate about providing quality education to all children. Born in 1870, at a time where few women attended college and were not expected to work in any area other than teaching, Maria grew up determined to become a doctor in spite of society, and even her fatherÃ¢â¬â¢s reservations. She was not accepted into the University of Rome, but with her spirit of perseverance, Maria gainedRead MoreMaria Montessori : An Educational Philosopher967 Words Ã |Ã 4 PagesMaria Montessori was an educational philosopher acclaimed for her child-centered education method that primarily focused on childrenÃ¢â¬â¢s natural ability to learn information through the stages of development. Because her method was centered around children, Montessori believed that the classroom environment and materials must be designed to foster childrenÃ¢â¬â¢s natural desire to discover information within their environment (Society, 2016; Pendleton, 2015). According to No rthwest (2015), the guidingRead MoreThe Montessori Method: Origins of an Educational Innovation1151 Words Ã |Ã 5 PagesÃ¯ » ¿Maria Montessori Introduction Maria Montessori left a lasting mark on the education system all over the world (Montessori Gutek, 2004). Philosophers consider her as one of the most popular as well as accomplished educator of her time. Many universities and schools today study and utilize her philosophies and techniques. Her life involves a story of a remarkable achievement and perseverance. Maria Montessori considered the concept of teaching children to explore the world through the use of theRead MoreThe Educational Work Of Maria Montessori1349 Words Ã |Ã 6 PagesMaria Montessori was born on the 31st August 1870 in the town of Chiaravalle, Italy. Maria got her quest for knowledge from her parents who were both well educated. She started her education at a local state school and proceeded onto a technical institute where she intended to pursue a career in engineering. This was unusual at the time as there were barriers that constrained womenÃ¢â¬â¢s careers, leaving them with fewer options to pursue technica l careers than their male contemporaries. Even after graduating
Tuesday, May 5, 2020
Question: Describe about the Contraction of Tissue Engineered Oral Mucosa? Answer: 1. Tissue Engineered Oral Mucosa Models An Oral mucosa which is artificially engineered consisting full thickness generally resembles the normal oral mucosa. It consists of several components as identical to the natural element (Barbagli and Lazzeri, 2015). A lamina propria was comprising of the three-dimensional scaffold, which is infiltrated by fibroblasts. These fibroblasts produces extracellular matrix (Heller et al. 2015). This structure can be effectively mimicked by seeding the oral fibroblasts in a biocompatible porous scaffold. This is followed by a long-term culturing protocol in the fibroblast differentiation medium (Bhargava et al. 2011). A researcher might have trouble such as reduced fibroblast infiltration, lack of porosity, shrinkage of scaffold along with rapid biodegradation of scaffold (Amemiya et al. 2015). A Continuous Basement Membrane (CBM) which separates the epithelia with lamina propia is involved in the engineering protocol. The associated basement membrane is characterized by the Transmission Electron Microscope (TEM), which clearly highlights the lamina lucida, anchoring fibers, and the lamina densa (Bucchieri et al 2012). The Immunostaining technique for the basement membrane antigens (e.g., type IV collagen, Laminin, Bullous Pemiphigoid Antigen, Fibronectin and Integrin) are considered quite useful for the characterization method (Cheng and Xie, 2012). A Stratified Squamous Epithelium is associated with the packed keratinocytes which is consist of basement membrane, undergoes migration to the surface of the buccal cavity. This structure can be efficiently imitated by the growth influence of in vitro keratinocytes of the oral cavity at an air and liquid interface within a transparent medium (containing keratinocyte growth factors, including Epidermal Growth Factor- EGF). The significant factors, which need to be highlighted, include the construction of keratinocyte invasion within the connective tissue layer (Bhargava et al. 2011). In order to speak to the difficulties and for the optimization in the construction of oral mucosa with full thickness, several factors need to be considered. This includes the following: i) Scaffolds ii) Cell Source iii) Culture Medium The detailed analysis of each of these structures are highlighted below: i) Scaffolds The scaffold is considered as in an important element of the oral mucosa. It helps to support the cells of associated to the surface. Thereby, choosing the suitable scaffold would be highly recommendable. An appropriate scaffold would include effective biocompatibility, biostability, porosity along with efficient mechanical properties(Amemiya et al. 2015). The scaffolds, which are used in the oral mucosa along with the skin reconstruction techniques, are found to be associated with several distinct categories. These are as follows; The details of each of the structures are mentioned below: a) Fibroblast-populated skin substitutes b)Naturally derived Scaffolds (acellular dermis and the amniotic membrane) c) Collagen-based scaffolds d) Fibrin based materials e) Gelatin based scaffolds f) Hybrid Scaffolds g) Synthetic Scaffolds (polymers) Naturally Derived Scaffolds Acellular Dermis Acellular Cadaveric Dermis under the brand name AlloDermTM is a scaffold, which is generally used for tissue engineering especially in the oral mucosa. It is non-immunogenic which has dual polarity. One side consists of the basal lamina, which is suitable for the epithelial cells. On the other hand, the perfect channels of the vessel are influenced by the fibroblast infiltration (Dickhuth et al. 2015). The De-Epidermalized Dermis (DED) are used for the preparation of epidermal-dermal composites. It is subsequently used for reconstruction of hard palate mucosal epithelium samples. The De-Epidermalized Bovine Tongue Mucosa is used as a substrate for the keratinocyte culture (Amemiya et al. 2015). The De-Epidermalized Dermis is generally prepared from the thickned skin with split texture on removing the epidermis and the dermal fibroblasts. The basic advantages of De-Epidermalized Dermis (DED) are as follows: a) Ability to retain the structural properties (even at low temperature or frozen) b) Lyophilization c) Ability to remain preserved in glycerol solution Collagen-based Scaffolds Pure Collagen Scaffolds Various scientists and researchers have developed the in vitro oral mucosal model by culturing normal keratinocytes on skin collagen isolated from the bovines in gels containing fibroblasts. Further, this set up was co-cultured in reconstruction medium (Barbagli and Lazzeri, 2015). By developing this technique, they have made a well defined mucosal model that is similar to the local tissues. In further research works scientists developed this model and they cultured oral mucosal tissue by using a telopeptide type I mixed with sponge matrix of contracted bovine skin collagen gels (CCG). This model was composed of lamina propia and fibroblasts embedded in CCG and collagen sponge and cell layers of stratified cell layers present in the surface of the lamina propia (Gauvin et al. 2012). The advantage of this model is that it provides a substrate and base for the formation of keratinocyte multilayer (Barbagli and Lazzeri, 2015). The significant finding of this research model was the detec tion of laminin expression between the epithelium tissue and lamina propia. However, expression of type IV collagen and hemodesmosome is not recognized and found during this experiment. Moreover, it was found that higher amount of extracellular matrix (ECM) was synthesized in three dimensional porous scaffold model (Heller et al. 2015). This scaffold model was named after the founder and is known as Moriyamas model. In further research and experiments, Roubhia and Deslauriers carried out another technique in which they mixed bovine skin collagen with the oral fibroblasts of the normal human being and produced engineered lamina propia (Dickhuth et al. 2015). They further seeded oral epithelial cells on this matrix and allowed them to grow and proliferate in an air-liquid interface. However, to track the proliferation rate of the oral epithelial cells the increase in the production of marker Ki-67 and cytokeratins K14, K19, K10 was measured (Barbagli and Lazzeri, 2015). It has been fo und that Keratinocytes interacts by producing laminarin basement proteins and integrins with the fibroblast. Moreover, this experiment also showed that oral mucosa can produce TNF- (tumor necrosis factor alpha), interleukins like IL-1 and IL-8, metalloproteases like gelatinase A and gelatinase B. However, it was found that collagen-based scaffolds have poor mechanical properties and cross linking of collagen tissues results in calcification (Bhargava et al. 2011). i) Cell Source Apart from the Scaffold, the other important factor, which needs to be considered in oral mucosa, is the type and origin of keratinocytes and fibroblasts. The fibroblasts are generally isolated on the primary dermal layer of skin by an oral mucosal biopsy. These tissues are used for early passage associated with the tissue engineering (Lanzaet al. 2011). This is because the extracellular matrix production that provided by the dermal fibroblasts tends to decrease, as the passage number increases. The Keratinocytes are found to be obtained from different sites in an oral cavity (e.g. hard palate). The usual active human keratinocytes need to be used at the early passage. However, the immortalized keratinocytes (e.g. HaCaT cells or TR146 cells) can be efficiently used in the reconstruction of oral mucosal test models in respect to its extended passage (Barbagli and Lazzeri, 2015). On the other hand, the epidermal differentiation associated with the transformed keratinocytes is considere d imperfect as the decisive steps of terminal differentiation does not take place. The tumor cells are considered anomalous and thereby it is not used for any clinical usage (Gil et al. 2015). ii) Culture Medium Frequently used cultural medium associated with the oral mucosa reconstruction is the Dulbeccos Modified Eagle Medium (DMEM)-Hams F-12 Medium (3:1). This is usually supplemented with the Fetal Calf Serum (FCS) along with other elements such as Glutamine, Adenine, Insulin, Epidermal Growth Factor (EGF), Transferrin, Tri-Iodothyronine, Hydrocortisone, Fungizone, Streptomycin, and Penicillin (Heller et al. 2015). Human Oral Mucosa which is formed by tissue engineering, was found to be equivalent to the Serum-free culture medium, was considered as an efficient protocol, associated with the context (Dickhuth et al. 2015). The elimination of the usage of serum and thereby the irradiation of mouse fibroblast feeder layers are associated with this memorandum, which minimized the exposure of human grafts recipients. This is related to the effect of the xenogeneic DNA which is present in the irradiates mouse 3T3 cells and the serum. It can be analyzed that the same techniques were followed for the human conjunctiva along with the oral mucosa corresponding (Cheng and Xie, 2012). The demonstration was based on the fact that the keratinocytes of oral mucosa and its perfusion is associated with the medium. Moreover, it is observed that it enhances the viability of the cell along with the proliferation while cultured in porous three-dimensional (3D) matrix of collagen-GAG. This provides a cross-linkage between the glutaraldehyde structures associated with the model (Brauchle and SchenkeÃ ¢Ã¢â ¬Ã Layland, 2013). Contraction of the tissue highlights towards the movement of the muscles, which is mainly regulated by several co-factors. Myofibroblast plays a cruicial role in the contraction mechanism. It helps to decrease the size of the muscle by gripping towards the edges of the muscles. This is mostly present within the smooth muscle cells. Both the effects of cell proliferation along with apoptosis is monitored by the phenomenon of contraction, which is effectively monitored in this experiment (Osman et al 2015). 2. Spectral Profile of Controlled and Drug Induced Model Proper monitoring of the tissue-engineered constructs is considered as an important component for the successful implementation of any tissue engineered techniques. To demonstrate and monitor the visible biochemical changes within the collagen cross-links of both controlled and drug-induced tissue engineered model, Raman spectroscopy is primarily used (Brauchle and SchenkeÃ ¢Ã¢â ¬Ã Layland, 2013). Raman spectroscopy provides a simple and rapid method for monitoring the quality of the tissue-engineered components and thus contains information regarding the biochemical properties of the cells and tissues (Gauvin et al. 2012). The application of the infrared Raman spectroscopy may be demonstrated by monitoring the tissue engineered constructs, which are stressed by high temperature and are exposed to a high concentration of calcium (much higher than the normal value) (Gauvin et al. 2012). Thus, analyzing the Raman spectra helps in understanding the correlation of the CH2 deformatio n ratio about the phenylalanine ring. The histology and the morphological changes of the tissue-engineered mucosa provide the data regarding the concentration of the glucose consumption that helps in revealing information regarding the specific and sensitive changes in the secondary structure of the protein. Tissue-engineered oral mucosa cells have been treated with a particular antibiotic rapamycin, which helps in understanding the proliferation and capacity of the cells (Cheng and Xie, 2012). A separate set of control has also been kept for making a clear distinction between the control and the rapamycin treated tissue engineered cells (Cheng and Xie, 2012). Figure 1.Raman spectroscopy showing the change in wavelength Introduction of a sugar molecule (for example mannitol, sorbitol, and glucose) during the process of tissue engineering has been analyzed by implementing the method of FTIR (Fourier Transform Infrared Spectroscopy). The studies helps in understanding the interaction between the chitostana and the gelatin fibres present which helps in the formation of the ionic and covalent bonds. The bonding helps in making strong collagen fibres, which helped in revealing the structure of the collagen fibres (Cheng and Xie, 2012). Thus spectral analysis by FTIR helps in understanding and revealing the nature and bonding of the collagen fibres during the process of tissue engineering (Votteler et al. 2012). Tissue engineering is considered as one of the most dynamic and important method for assisting tissue engineering of oral mucosa. The analysis by Raman spectra also reveals the data in response to the present of an antibiotic. Thus, it can be stated that in presence of an antibiotic rapamycin ther e is a change little increase in the wavelength in presence of an antibiotic (Brauchle and SchenkeÃ ¢Ã¢â ¬Ã Layland, 2013). The Raman spectroscopy has been supported by the FTIR analysis, which helps in understanding regarding the various surface properties associated with the introduction of the antibiotic. The FTIR analysis also helps in understanding regarding the change in wave number in accordance with the spectral data produced and thus helps in facilitating the proper tissue engineering techniques in terms of oral cell mucosa (Gauvin et al. 2012). This also helps to assess the various numbers of biochemical changes produced in normal skin caused by the tissue engineered oral cell mucosa. Cluster analysis helps in the evaluation of the vibration modes, which is associated in understanding and revealing the structure of the associated protein, which indicates changes in the secondary conformation of the various changes in the tissue. FTIR spectra are primarily acquired in aspect of three experimental configuration which includes transmission, reflection-absorption and total reflection which includes the fraction of total attenuated radiation (ATR). The spectral analysis also helps in understanding of the various anatompophological characteristics of both the control and the antibiotic treated tissue cells (Heller et al. 2015). Thus, the present change in the wavelength and wave numbers of a particular tissue represents a valuable data for organ and tissue reconstruction (Barbagli and Lazzeri, 2015). The control has been subjected to two different kinds of stress, which includes thermal changes and increase in the concentration of the calcium. The changes helped in understanding regarding the various changes in the value of the wavelength in terms of the data obtained with the help of Raman spectroscopy and FTIR. The CH2 band ratios also helped in revealing the ratio of the phenylalanine bonds in terms of thermal stress and higher concentration of the calcium molecules. Thus, because of small variation in execution of the productive protocol, the specific variability in the tissue engineered cells can be understood (Cheng and Xie, 2012). Thus, both Raman and FTIR provide effective data in understanding the overall change in the wavelength produced in response to the presence of antibiotic rapamycin. The antibiotic rapamycin thus disrupts the various bonds and thereby leads to an overall increase in the wavelength of the resulting spectroscopy analysis (Dickhuth et al. 2015). 3. Monitoring the effects of B-APN The effect of APN on a drug induced model is described in the graph presented below: It can be analyzed from this graphical interpretation that there is a considerable increase in the slope. The activity of absorbance doubles itself within 60 minutes, which highlights towards the higher efficiency of the graphical analysis (Heller et al. 2015). 4. Constructing a Chemo-metric Modeling system Chemo-metrics would be an effective parameter related to the article. It reflects towards the usage of statistical and mathematical protocol in order to improve the understanding of chemical information and thereby correlate the quality parameters associated to it. The patterns of the data are modeled, which are routinely applied to the future data to predict the same quality parameters (Cheng and Xie, 2012). The result attained from the chemo-metric approach focuses towards gaining efficiencies in assessing the product quality. More efficient laboratory practices are highlighted through this quality control system. Hence, for constructing the chemo-metric modeling system for analyzing the spectral data, an appropriate instrumentation along with an effective and interconnectivity software (for interpreting the patterns of the obtained data) needs to be implemented on the primary basis (Bhargava et al. 2011). Chemo-metrics provides the spectroscopists the various ways to solve the calibration issues, which are interrelated to the spectral data. It is recommendable that the construction of chemo-metric modeling system should be monitored is such a way that helps to enhance the developmental methods significantly and thereby make effective routine use of the statistical models for data analysis(Amemiya et al. 2015). Implementing Unscrambler for analyzing the spectroscopic data, modeling, classifying the data analyzed and thereby predicting to meet the protocol of quality assurance and monitoring would be an effective step related to the context. The researcher would be requiring other equipments for constructing an effective chemo-metric system which are stated below: A Spectroscopic data pre processing unit, which would help to reduce and thereby rectify the interferences such as overlapped bands, scattering, baseline drifts and the path length variations is considered as the primary equipment associated to the research study (Gauvin et al. 2012). Recommending Multiplicative Scatter Correction (MSC) pretreatment device would be effective as it would focus towards building a reliable relationship between the cell structure content present within the tissue engineered oral mucosa and the spectral data for scatter correction (Brauchle and SchenkeÃ ¢Ã¢â ¬Ã Layland, 2013). Establishing an effective Calibration and Diagnostic means of sample from the tissue engineered oral mucosa would be effective for the system. Variable selection of the sample would be helpful in deducing an effective result calculation and thereby rebuilding representative and reliable model (Gil et al. 2015). Model integration along with Model Validation would be helpful in develop the rigorous prediction system. Considerable it would be helpful in measuring the Quality Control (QC) and formulating the relative time product quality and protocol monitoring (Cheng and Xie, 2012). Apart from these requirements, the spectroscopists would be requiring the following chemo-metric software package in order to deduce the data associated to the context. This includes the following: Principal Component Analysis (PCA) SIMCA and PLS-DA Classification Regression (PLS, PCR, MLR, 3-way PLS) and Prediction (Heller et al. 2015) After gathering all the equipments along with the software package, the basic data analysis process is carried out in a systematic order. Figure: Flowchart representing the protocol for Chemo-metric System (Gil et al. 2015) Data input is considered as the most overlooked stage associated to the protocol. This is the main crucial stage in the entire instrumentation (Gauvin et al. 2012). The data, which is analyzed, is efficiently transferred into the software device. The proprietary collection software converts this protocol in a complex manner. The outliers are removed subsequently, which is considered as a delicate procedure. This is followed by a Grubbs test, which mainly helps to detect the outliers. The false outliers, which are present at the extreme point f the system and thereby appear infrequently within the data are subsequently removed (Amemiya et al. 2015). On the other hand, the true outliers (samples and variables which are statistically different from one another) are effectively removed (Barbagli and Lazzeri, 2015). The next stage involves the protocol of Preprocessing. The main goal associated to the preprocessing stage involves the removal of variation within the data, which does not pertain to the analytical information (Brauchle and SchenkeÃ ¢Ã¢â ¬Ã Layland, 2013). The typical preprocessing methods, which can be analyzed for evaluating the cell lines of oral mucosa, would include the following: Baseline Correction Mean Centering Normalization Orthogonal Signal Correction Multiplicative Scatter Correction Savitsky-Golay Derivatisation The output, which is attained from this experimental setup, is mainly classified into two types, i.e. Qualitative and Quantitative segments. The Qualitative model would mainly highlight the classified models, effects of classification and the evidences behind classification error. On the other hand, the Quantitative segment would focus towards the prediction models and the involvement of RMSEC and RMSEP (Bhargava et al. 2011). References Amemiya, T., Nakamura, T., Yamamoto, T., Kinoshita, S. and Kanamura, N., 2015. Autologous Transplantation of Oral Mucosal Epithelial Cell Sheets Cultured on an Amniotic Membrane Substrate for Intraoral Mucosal Defects. Barbagli, G. and Lazzeri, M., 2015. Clinical experience with urethral reconstruction using tissue-engineered oral mucosa: a quiet revolution.European urology,68(6), pp.917-918. Bhargava, S., Patterson, J.M., Inman, R.D., MacNeil, S. and Chapple, C.R., 2011. Tissue-engineered buccal mucosa urethroplastyclinical outcomes.European urology,53(6), pp.1263-1271. Brauchle, E. and SchenkeÃ ¢Ã¢â ¬Ã Layland, K., 2013. Raman spectroscopy in biomedicinenonÃ ¢Ã¢â ¬Ã invasive in vitro analysis of cells and extracellular matrix components in tissues.Biotechnology journal,8(3), pp.288-297. Bucchieri, F., Fucarino, A., Marino Gammazza, A., Pitruzzella, A., Marciano, V., Paderni, C., De Caro, V., Gabriella Siragusa, M., Lo Muzio, L., T Holgate, S. and E Davies, D., 2012. Medium-term culture of normal human oral mucosa: a novel three-dimensional model to study the effectiveness of drugs administration.Current pharmaceutical design,18(34), pp.5421-5430. Cheng, J.X. and Xie, X.S. eds., 2012.Coherent Raman scattering microscopy. CRC press. Chung, B.G., Lee, K.H., Khademhosseini, A. and Lee, S.H., 2012. Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering.Lab on a Chip,12(1), pp.45-59. Dickhuth, J., Koerdt, S., Kriegebaum, U., Linz, C., Mller-Richter, U.D., Ristow, O., Kbler, A.C. and Reuther, T., 2015. In vitro study on proliferation kinetics of oral mucosal keratinocytes.Oral surgery, oral medicine, oral pathology and oral radiology,120(4), pp.429-435. Gauvin, R., Chen, Y.C., Lee, J.W., Soman, P., Zorlutuna, P., Nichol, J.W., Bae, H., Chen, S. and Khademhosseini, A., 2012. Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography.Biomaterials,33(15), pp.3824-3834. Gil, R.S., Pags, C.M., Dez, E.G., Llames, S., Fuertes, A.F. and Vilagran, J.L., 2015. Tissue-Engineered Oral Mucosa Grafts for Intraoral Lining Reconstruction of the Maxilla and Mandible With a Fibula Flap.Journal of Oral and Maxillofacial Surgery,73(1), pp.195-e1. Heller, M., Frerick-Ochs, E.V., Bauer, H.K., Schiegnitz, E., Flesch, D., Brieger, J., Stein, R., Al-Nawas, B., Brochhausen, C., Throff, J.W. and Unger, R.E., 2015. Tissue engineered pre-vascularized buccal mucosa equivalents utilizing a primary triculture of epithelial cells, endothelial cells and fibroblasts.Biomaterials,77, pp.207-215. Kim, C.Y., Woo, Y.J., Lee, S.Y. and Yoon, J.S., 2014. Postoperative Outcomes of Anophthalmic Socket Reconstruction Using an Autologous Buccal Mucosa Graft.Journal of Craniofacial Surgery,25(4), pp.1171-1174. Kim, R.Y., Fasi, A.C. and Feinberg, S.E., 2014. Soft tissue engineering in craniomaxillofacial surgery.Annals of maxillofacial surgery,4(1), p.4. Kinikoglu, B., Damour, O. and Hasirci, V., 2015. Tissue engineering of oral mucosa: a shared concept with skin.Journal of Artificial Organs,18(1), pp.8-19. Lanza, R., Langer, R. and Vacanti, J.P. eds., 2011.Principles of tissue engineering. Academic press. Lu, Q., Al-Sheikh, O., Elisseeff, J.H. and Grant, M.P., 2015. Biomaterials and tissue engineering strategies for conjunctival reconstruction and dry eye treatment.Middle East African journal of ophthalmology,22(4), p.428. Lv, X.G., Feng, C., Fu, Q., Xie, H., Wang, Y., Huang, J.W., Xie, M.K., Atala, A., Xu, Y.M. and Zhao, W.X., 2015. Comparative study of different seeding methods based on a multilayer SIS scaffold: Which is the optimal procedure for urethral tissue engineering?.Journal of Biomedical Materials Research Part B: Applied Biomaterials. MacNeil, S., 2012. Biomaterials for tissue engineering of skin.Materials today,11(5), pp.26-35. MacNeil, S., Shepherd, J. and Smith, L., 2011. Production of tissue-engineered skin and oral mucosa for clinical and experimental use. In3D cell culture(pp. 129-153). Humana Press. Moharamzadeh, K., Brook, I.M., Van Noort, R., Scutt, A.M. and Thornhill, M.H., 2007. Tissue-engineered oral mucosa: a review of the scientific literature.Journal of dental research,86(2), pp.115-124. Moharamzadeh, K., Colley, H., Murdoch, C., Hearnden, V., Chai, W.L., Brook, I.M., Thornhill, M.H. and MacNeil, S., 2012. Tissue-engineered oral mucosa.Journal of dental research,91(7), pp.642-650. Neel, E.A.A., Chrzanowski, W., Salih, V.M., Kim, H.W. and Knowles, J.C., 2014. Tissue engineering in dentistry.Journal of dentistry,42(8), pp.915-928. Nunes, l.f.m., de nazar alves de oliveira, c.a.m.i.l.a., dos santos, e.b. and MESQUITA, R.A., 2014. Epidemiology of the Oral Mucosa Lesion in Elderly Patients.Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,117(2), p.e205. Oie, Y., Hayashi, R., Takagi, R., Yamato, M., Takayanagi, H., Tano, Y. and Nishida, K., 2010. 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Sunday, April 19, 2020
Water Conservation Satire Essay There has been a severe drought that plagues the Social region and much of the entire state of California. Water prices have increased to unforeseen highs and the government unsuccessfully attempted to regulate the frequency at which our sprinklers feed our thirsty vegetation. Would like to offer a more effective solution to this problem, because the key to water conservation is starting at home. Men, women, children, and even pets (which we will not account for, even though bathing animals exacerbates the problem) all require frequent thing, which is the sole contributor to our drought. Men tend to take quicker showers, approximately ten minutes each, while women and children can last for up to fifteen minutes or longer per shower. Considering the average five minute shower requires twenty five gallons Of water, and each human showers once a day, an average family of four, consisting of a man, a woman, and two children, will consume 50+xx=275 gallons of water per day. Only about ten cups of water are necessary to satisfy daily drinking requirements per person, and the amount of water used in showers that day s more than 100 times that. I propose that we stop showering altogether. This would save an incredible amount of water that could be put to much better use. According to my calculations, we will even enter an era of water surplus, in which we can sell the excess water to other areas that need it, and bolster our local economies in the process. Eventually people in other drought-stricken areas will learn from us and cease to continue such wasteful bathing habits. Some might worry about body odors that might arise after prolonged roods away from the shower. We will write a custom essay sample on Water Conservation Satire specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Water Conservation Satire specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Water Conservation Satire specifically for you FOR ONLY $16.38 $13.9/page Hire Writer However, water conservation is a greater issue with a greater need of solving, and therefore should hold the utmost pertinence. Body odor can easily be solved with the increased application of sanitary products, such as deodorant or wipes. The views and smells of society will change. Those with the greasiest hair and smelliest armpits will be the champions of society, for they have demonstrated their unbeatable passion for resolving detrimental issues. They will be respected and honored as heroes.
Saturday, March 14, 2020
How to Write an Informative Essay on Strategic Marketing Management When writing the informative essay, your overall goal is to inform your audience of something related to your course, or subject matter. To that end, you want to inform the reader on an important facet of a problem or situation. For example: you may want to tell your readers about health, but in so doing you have to whittle down your topic to something which you can easily explore and analyze in the number of pages or word limit you have been given. Topics Start by picking your broad topic. In most cases the first idea you have will not be small enough to be adequately covered. You want to be able to integrate some claims and supporting evidence such that by the end of reading your essay a reader is better informed on the issue at hand. Should your topic be too broad, you will be unable to do that well. To narrow down your topic, try to refine it by a specific demographic data such as: Age Location Gender Ethnic groups Occupation Time period For example: if you choose management, and you narrow it down to the prevalence of conflict in one department, or under one leader, you can refine it by a type of conflict or by a demographic such as males versus females or older employees versus younger employees. Research After the selection of your topic, you must begin the research. Bring with you things such as: Notecards of different colors Pens Highlighters Because you need evidence in order to properly inform, it will save you a great deal of time to bring notecards of various colors so that one color can highlight key ideas and the other color can be designated for supporting documentation. When you find a quote or statistic you want to use, write it down with the bibliographic information, or make a photocopy and highlight the portion you want to use. This seems remedial, and many students believe that once they find a key idea or statistic they will know exactly what it is at any point in the future; however, most students find that when it hits crunch time and they are frantically writing in search for that one idea they remember how they spot in a specific study that key idea but it is lost to them now. If you highlight it, it will not be lost. Evidence When presenting your evidence, you need to remain objective. This is not a personal piece where you inform the reader of your opinion. Rather, it is an academic piece where you must present evidence to support your claims. In cases like these the evidence comes in the form of: Scientific studies Data Quotes from experts in the field Anecdotes Statistics Writing With your notes and evidence, it is time to start writing. Generally, the structure of the informative essay is on par with the standard five paragraph essay insofar as you need an introduction, body, and conclusion. You should set aside a single body paragraph for each of the key ideas you are presenting in support of your thesis. If you need more information on strategic marketing management for your paper, check out 20 topics on marketing management with a sample essay. Furthermore, you have a chance to see full scale facts on the same issue that will help yourÃ informative essay writing.
Thursday, February 27, 2020
Missouri Inchoate Crimes - Essay Example The present study focuses on the statute for inchoate crimes in Missuori and compares it with the historical common law for the same and hence studies the differences. Missouri and its Statute for Inchoate Crimes: In the present study, focus has been concerned with the cases of attempt and conspiracy. As far as the statutes of the inchoate crimes in Missouri are concerned, the elements of the statutes may be learnt as follows. Missouri Laws 564.011 Ã¢â¬â Attempt: The Elements: 564.011. 1: Based on this statute, an individual is held responsible for attempting an act of crime where he intends to take some step in accomplishing an act of crime. A considerable measure is accomplished which is powerfully supportive of the resolution of the purpose of the criminal to accomplish the charge of the crime (Missouri Laws 564.011 Ã¢â¬â Attempt, 2009). 2. According to this section, it is not a resistance to a trial that the crime tried to be committed was, under the genuine conditions of s upport, literally or lawfully impractical of occurrence, in case such crime could have been attempted when the conditions of the support were the actor as could be supposed (Missouri Laws 564.011 Ã¢â¬â Attempt, 2009). 3. ... Missouri Laws 564.016 Ã¢â¬â Conspiracy: The Elements: 564.016. 1. According to this section, an individual is accountable for conspiracy with other individuals to commit a crime if, he agrees with the others that they would be involved in such misconduct (Missouri Laws 564.016 Ã¢â¬â Conspiracy, 2009). 2. In case of an individual conspiring with another person or other individuals who are already involved in some other conspiracy then this person is also considered to be a part of the other conspiracy as well (Missouri Laws 564.016 Ã¢â¬â Conspiracy, 2009). 3. When an individual conspires to commit numerous crimes, he is considered accountable for only a single conspiracy where the other offenses are the objectives of the same accord (Missouri Laws 564.016 Ã¢â¬â Conspiracy, 2009). 4. An individual cannot be held guilty of conspiracy if an evident criminal act associated with the conspiracy is not suspected and proved to have been accomplished by him or the other individuals involved in the conspiracy (Missouri Laws 564.016 Ã¢â¬â Conspiracy, 2009). 5. (1) An individual cannot be held guilty of conspiracy if, after the plan of conspiracy of a criminal act, he prohibited the execution of the goals of the conspiracy in case of situations where he wishes to abandon his act; (2) The defendant is supposed to have the trouble of introducing the matter of abandonment of Ã¢â¬Å"criminal purpose under subdivision (1) of this subsectionÃ¢â¬ (Missouri Laws 564.016 Ã¢â¬â Conspiracy, 2009). 6. Considering the limitations of time on trials: (1) Conspiracy has been considered as an ongoing path of demeanor which expires when the acts of the crimes are abandoned by the conspirer himself; (2) If an individual discards his plan, the
Tuesday, February 11, 2020
Enron and Ethics - Essay Example Arthur Anderson was recognized by the industry as one of the most prestigious accounting firms in the world. Even though the accounting scam Enron was running was a bit complex, a top accounting firm such as Arthur Anderson should have been able to recognize the accounting irregularities. The accounting firm turned a blind eye and they let the accounting scam continue for years. The Securities and Exchange Commission also did not do a good job of recognizing the scam in time. The SEC failed to perform its job of protecting the investors since they had at their disposal every annual report of the company with its financial statements and they fail to notice the scam the firm was running. The ethical meltdown the firm endured occurred because the executive managerial staff of the company was greedy and extremely unethical. They envision the company as the market leader in its industry when in reality the company had a business model that was completely flawed. At the end of the debacle when things were going down and the scam was revealed the top executives sold their shares fast before they completely lost all their value. The scam was such a secret that even president George Bush was a big backer of the company (Lashinsky, 2001). 2.